Objective. The aim of this study was to use quantitative sensory testing (QST) to explore the range and prevalence of somatosensory abnormalities demonstrated by patients with advanced knee OA. Methods. One hundred and seven knee OA patients and 50 age- and sex-matched healthy p

Researchers at the Rothman Institute at Jefferson have shown that local anesthesia delivered through a catheter in the joint, intraarticularly, may be more beneficial than traditional opioids such as morphine and Oxycontin for pain management following total knee replacement surg

A new study has demonstrated that a procedure wherein healthy cartilage is transplanted to fix an area of damaged cartilage (osteoarticular cartilage transplantation or OATS procedure) is superior to the standard of care for repairing cartilage defects...

A 12-month randomized double blind clinical trial in 60 patients with active erosive hand osteoarthritis compared TNF blockade using adalimumab (40 mg fortnightly subcutaneous administration) with placebo. Whereas no benefit could be attributed to adalimumab overall, the drug sig

Obesity is on the increase worldwide, and is associated not only with type 2 diabetes mellitus, but also osteoarthritis (OA). New data published in Arthritis Research & Therapy support the theory that the metabolic dysfunction that occurs with obesity can increase OA progression

Telomeres, the very ends of chromosomes, become shorter as we age. When a cell divides it first duplicates its DNA and, because the DNA replication machinery fails to get all the way to the end, with each successive cell division a little bit more is missed...

A comprehensive review of herbal medicine products in the latest issue of the Drug and Therapeutics Bulletin (DTB) shows that there is little conclusive evidence to justify the widespread use of herbal medicines to relieve the symptoms of the painful joint condition osteoarthriti

Tissue degradation resulting from injury to the knee menisci can lead to the development of osteoarthritis. Evidence suggests that cell accumulation at the meniscal lesion is important for repair of the damaged tissue and restoration of joint function. Now, data from Farshid Guil

The precise role that basic calcium phosphate microcrystals have in the pathogenesis of osteoarthritis (OA) is controversial. The recent paper by Jin et al. provides new insights into the potential mechanisms that link these microcrystals to joint damage, and highlights the role